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Highlights

CYTOPLATIN
Cisplatin is an anticancer (cytotoxic) medicine.Cancers form when some cells within the body multiply uncontrollably and abnormally. There are two types of cancer. Solid cancers where a lump forms e.g. the bone, muscle, brain cells etc. divide and multiply abnormally. The second type are leukaemias and lymphomas where the blood cells divide and multiply abnormally.Other characteristics of cancer besides uncontrolled growth include the ability of these abnormal cells to invade other tissues next to them or to break away from the original site, travel through the blood or lymph, and establish a new cancer at a different site of the body. These are called metastases.Like normal healthy cells, cancer cells go through a continuous process of change. Each cell divides into two daughter cells. These cells grow, rest and then divide again. The medicines used in chemotherapy are powerful chemicals designed to interupt this cycle and stop cells from growing.Several different types of anticancer medicines are used in chemotherapy. Each type kills cells at a different stage of the cell's life cycle. Each does its job in a different way.Cisplatin is a platinium (heavy metal) compound. It works by preventing the production of genetic material (DNA) by the cell. It does this by forming links with the strands of DNA and by doing so it binds them together. This prevents the cell from reproducing.Unfortunately, anticancer medicines will also affect the growth and division of normal, healthy cells in the same way, such as blood, gut and hair cells. This can therefore cause several of the side effects seen with chemotherapy e.g. hair loss. The body's immune system also becomes suppressed increasing the risk of infections.In most chemotherapy regimens, doses are administered in courses at various intervals to allow normal cells to recover from the adverse effects of the anticancer medicines between doses. However, during this period, cancer cells will also recover and start to replicate again. Successful treatment depends on the administration of the next course of therapy before the cancer has regrown to its previous size and the net effect is to decrease the amount of cancer with each successive course.Cisplatin is used principally in combination with other anticancer medicines. It is administered intravenously only.As well as the cancers listed below, cisplatin is undergoing trial in other types of cancer.What is it used for?Bladder cancer Cancer of the ovaries Cervical cancer Head and neck cancerLung cancer Testicular cancer

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