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Highlights

Cisapride
Cisapride is a 'prokinetic' agent that increases muscle contractions of the lower esophagus and the lower esophagus sphincter. The lower esophagus sphincter, located between the esophagus and stomach, normally prevents reflux of acid and other stomach contents into the esophagus. In patients with Gastroesophageal Reflux (GERD), a weakened lower esophagus sphincter allows reflux of stomach acid into the esophagus, causing heart burn and acid damage to the esophagus (peptic esophagitis). Cisapride, like metoclopramide (Reglan), decreases stomach acid reflux by strengthening the lower esophagus sphincter, as well as the peristaltic muscle contractions of the lower esophagus. These two medications also hasten the stomach emptying of solid and liquid meals into the intestines. Faster emptying of meals decrease the reflux of stomach acid and other contents into the esophagus. While cisapride and Reglan are similar in decreasing gastroesophageal reflux, Reglan is more likely to cause nervous system side effects such as jitteriness, insomnia, sedation, or anxiety.

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