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The chest pain of coronary heart disease (angina) usually occurs when the heart requires more blood and oxygen than its coronary vessels can deliver. This demand for oxygen is related, in part, to blood pressure. The demand for oxygen can be reduced in one of two ways. First, dilating the veins and pooling the blood lowers the blood pressure. Second, dilating the arteries reduces the pressure that the heart has to pump against. Isosorbide dinitrate reduces angina by dilating both the veins and the arteries. Isosorbide dinitrate is in the class of drugs called anti-anginal medications. Isosorbide dinitrate reduces the blood pressure as well as the capillary pressure (vascular resistance), improving the heart's efficiency. Isosorbide dinitrate is used for the treatment and prevention of angina. Isosorbide dinitrate can be used to decrease the frequency and severity of anginal (chest pain) episodes and to reduce the need for sublingual (taken under the tongue) nitroglycerine.
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