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Highlights

Glibenclamide
an oral hypoglycaemic agent, acts initially on the functioning beta cells of the pancreas to release insulin. Extrapancreatic activity (i.e. improvement in the binding of insulin to tissue insulin receptors and the increase in the number of the receptors themselves) may contribute to the mechanism of action of GLIBEN. Glibenclamide is completely metabolised. In the human body its breakdown takes place by hydroxylation of the cyclohexyl group. is used for treating non-insulin dependent type II diabetes, when diet alone is not adequate.

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