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THALODA Information: This medication is used to treat or prevent certain skin conditions related to Hansen's disease, once known as leprosy (erythema nodosum leprosum). Thalidomide is also used with other drugs to treat a certain type of cancer (multiple myeloma). Thalidomide belongs to a class of drugs known as immunomodulators. It works in Hansen's disease by reducing swelling and redness (inflammation). It also reduces the formation of blood vessels that feed tumors.OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This drug may also be used to treat certain conditions caused by cancer, HIV infection, and other diseases (e.g., Crohn's disease).How to use Thalidomide OralRead the Patient Information Leaflet provided by your pharmacist before you start using thalidomide and each time you get a refill. Read and sign the informed consent provided by your doctor. If you have any questions, consult your doctor or pharmacist.Take this medication by mouth with water, usually once daily at bedtime at least 1 hour after the evening meal or as directed by your doctor.Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased.Keep the capsules in their blister pack until ready to use. If any of the powder from the capsule gets on your skin, wash the area with soap and water.Since this drug can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from broken capsules. All people should wash their hands carefully after handling this drug.This medication passes into body fluids (e.g., urine). Avoid contact with body fluids from people taking this drug. Therefore, wear protective clothing (e.g., gloves) when handling these body fluids (e.g., during cleanup). If contact occurs, wash skin with soap and water.Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. If you are taking this medication for Hansen's disease, your skin condition may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased.Tell your doctor if your condition does not improve or if it worsens after 2 weeks.What conditions does this medication treat?Thalidomide Oral is used to treat the following:Acute Leprosy Reaction with Formation of Nodules, Prevention of Acute Leprosy Reaction with Nodule Formation, Multiple MyelomaThalidomide Oral may also be used to treat:Infection caused by Mycobacteria, Significant Weight Loss from HIV, A Chronic Multisystem Inflammatory Disorder, Brain Tumor, Porphyria Cutanea Tarda, Repeatedly Occurring Small Ulcers of the Mouth, Treatment to Prevent Recurrent Aphthous Stomatitis, Crohn's Disease, Pyoderma Gangrenosum, Erythema Multiforme, Disease that Causes Disc-Shaped Patches On the Upper Body, Skin Disease in Patients with Discoid Lupus Erythematosus, Swollen Itching Skin Lesions and Erosion of Skin, Chronic Skin Disease causing Very Itchy Nodules, Incompatibility Reaction Following Bone Marrow Transplant, Treatment to Prevent Reaction After Bone Marrow Transplant

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Heart disorder liver or kidney impairment pregnancy and breast feeding. This medicine acts directly on the smooth muscle in the gut causing it to relax. It also prevents nerve signals getting through to the muscle in the intestines. This also causes the muscle to relax, preventing painful muscle spasm. Little or no antispasmodic effect was seen on the uterus and the bronchial muscles. Gastric emptying time and intestinal propulsion were affected much less than by papaverine. No significant inhibition of normal peristalsis has been observed. Primary irritable colon characterised by persistent diarrhoea, alternating constipation and diarrhoea, abdominal pain and postprandial distension. Secondary irritable colon due to organic lesions such as regional enteritis, diverticulitis, specific and non-specific inflammatory conditions of the gastro-intestinal tract.

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