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Irbesartan is used to treat high blood pressure. It may be used alone or in combination with other drugs. It has less of an effect in black patients, an effect that is similar to another class of drugs used to treat high blood pressure called ACE inhibitors--captopril (Capoten), enalapril (Vasotec), benazepril (Lotensin), and lisinopril (Zestril). Irbesartan is being studied in patients with congestive heart failure to determine if its blood pressure-lowering effects are beneficial to the heart. Irbesartan is among a class of drugs called angiotensin receptor blockers and is similar to losartan (Cozaar) and valsartan (Diovan). All three drugs block angiotensin II, a chemical that causes the arteries and veins to narrow, from attaching to the arteries and veins and causing them to narrow. As a result, the arteries and veins dilate (become larger), and blood pressure is reduced. When the blood pressure is reduced, the heart doesn''t have to work as hard to pump blood.

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