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Cefixime is a semisynthetic cephalosporin antibiotic, chemically similar to penicillin. It is effective against a wide variety of bacteria organisms, such as Streptococcus pneumoniae, Haemophilus influenzae, E. coli, N. gonorrhoeae, and many others. Cefixime is effective against susceptible bacterias causing infections of the middle ear, tonsillitis, throat infections, laryngitis, bronchitis, and pneumonia. It is used in treating urinary tract infections and gonorrhea. It is also useful in treating acute bacterial bronchitis in patients with chronic obstructive pulmonary disease (COPD). Cefixime should be avoided by patients with a known allergy to cephalosporin type antibiotics. Since cefixime is chemically related to penicillin, an occasional patient can have an allergic reaction (sometimes even anaphylaxis) to both medications. Treatment with cefixime and other antibiotics can alter the normal bacteria flora of the colon and permit overgrowth of C. difficile, a bacteria responsible for pseudomembranous colitis. Patients who develop pseudomembranous colitis as a result of antibiotics treatment can experience diarrhea, abdominal pain, fever, and sometimes even shock.
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