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Pentoxifylline is used in patients with poor circulation of the limbs and that have intermittent claudication. Intermittent claudication causes pain in the leg when you walk. Although not approved for other use, it is often for circulation problems brought on by diabetes, sickle-cell anemia, Raynaud''s syndrome, and other conditions. Pentoxifylline decreases the 'stickiness' (viscosity) of blood and thereby improves its flow. This increase blood flow helps patients with peripheral arterial disease to obtain better circulation and oxygen delivery to vital tissues. Pentoxifylline is used in patients to treat a condition of painful legs that develop with exercise because of inadequate circulation to the legs and feet (intermittent claudication).
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