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Ramipril is used for the treatment of heart failure (congestive heart failure or CHF) and high blood pressure (hypertension). Treatment also prevents heart attacks, strokes and deaths due to heart disease. Ramipril slows the progression of kidney failure in patients with diabetes. Ramipril belongs in a class of drugs called angiotensin converting enzyme (ACE) inhibitors which are used for treating high blood pressure and heart failure and for preventing kidney failure due to high blood pressure and diabetes. Other ACE inhibitors are enalapril (Vasotec), quinapril (Accupril), captopril (Capoten), fosinopril (Monopril), benazepril (Lotensin), lisinopril (Zestril, Prinivil), moexipril (Univasc) and trandolapril (Mavik). ACE is important because it produces the protein, angiotensin II. Angiotensin II contracts the muscles of most arteries in the body, including the heart, thereby narrowing the arteries and elevating the blood pressure. In the kidney, the narrowing caused by angiotensin II also increases blood pressure and decreases the flow of blood. ACE inhibitors such as ramipril lower blood pressure by reducing the production of angiotensin II, thereby relaxing the arterial muscles and enlarging the arteries. The enlargement of the arteries throughout the body reduces the blood pressure against which the heart must pump blood, and it becomes easier for the heart to pump blood.
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