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Medroxyprogesterone is a progestin that is derived from the naturally occurring female hormone, progesterone. Progestins and estrogens comprise the two major classes of female hormones. Medroxyprogesterone is used to treat abnormal uterine bleeding, promote menstrual cycles, and to treat symptoms of the menopause. Progestins are responsible for changes in the mucus and inner lining of the uterus (endometrium) during the second half (secretory phase) of the menstrual cycle. Progestins prepare the endometrium for implantation of the embryo, and once an embryo implants in the endometrium, i.e., pregnancy occurs, progestins help maintain the pregnancy. At high doses, progestins also prevent ovulation (release of the egg from the ovary). Medroxyprogesterone is used to promote menstruation when women do not begin naturally to menstruate at puberty (called primary amenorrhea) or if they stop menstruating before menopause (called secondary amenorrhea). Medroxyprogesterone also is used for treating abnormal bleeding from the uterus in many situations, though only after attempts to determine the cause of bleeding have been made. It is not used to treat bleeding due to fibroids, tumors, or other correctable causes of bleeding. Medroxyprogesterone is used in combination with estrogens for treating symptoms of menopause in order to prevent unchecked growth of the endometrium that may lead to endometrial cancer. It also is used for treating the pain of endometriosis.
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