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Carbimazole is used to treat hyperthyroidism. It prevents the peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the T3/T4. Carbimazole acts to prevent the conversion of iodine to its useable form. Carbimazole also acts to block the combination of converted iodine with other components to form thyroid hormones. This results in a decreased production of thyroid hormones. Carbimazole does not immediately decrease the blood levels of thyroid hormones, because the existing high levels of thyroid hormones already produced by the thyroid gland must be used up by the body. This means it may take three to four weeks after starting carbimazole treatment before the thyroid hormone levels begin to decrease. Some improvement is usually felt within one to three weeks. However, full beneficial effects usually take four to eight weeks. Carbimazole is used to reduce production of thyroid hormones when excessive amounts are being produced by an overactive thyroid gland (hyperthyroidism). In some people this medicine may be enough to treat the condition and return thyroid function to normal. You may need to take this medicine for several months in order to maintain control of the thyroid gland.
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