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Famciclovir is an antiviral drug which is active against the Herpes viruses, including herpes simplex 1 and 2 (cold sores and genital herpes) and varicella-zoster (shingles and chicken pox). It inhibits the replication of viral DNA that is necessary in order for viruses to reproduce themselves. Famciclovir is actually a 'prodrug,' in that it is not active directly against viruses. Instead, famciclovir is converted to penciclovir in the body, and it is the penciclovir that is active against the viruses. (Penciclovir also is available as a topical and intravenous medication.) Famciclovir is active against the same viruses as acyclovir but has a longer duration of action. Famciclovir is used to treat the first episode of genital herpes and to treat patients with recurrent (more than 6 episodes per year) severe genital herpes. Famciclovir reduces the pain and the number of sores with the first episode and decreases the frequency and severity of episodes in individuals with recurrent episodes. In the treatment of shingles, famciclovir reduces pain, shortens the time in which sores heal, and limits the spread of virus and the formation of new sores. Famciclovir can be used to treat chicken pox to reduce healing time, limit the number of sores (pox), and reduce fever if used within the first 24 hours after the onset of the disease.
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