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Lantus Optipen Information: Lantus Optipen (Insulin glargine)Category: Antidiabetic agent

Insulin glargine is a type of insulin. Insulin is one of many hormones that help the body turn the food we eat into energy. This is done by using the glucose (sugar) in the blood as quick energy. Also, insulin helps us store energy that we can use later. When you have diabetes mellitus (sugar diabetes), your body does not produce enough insulin, or the insulin produced is not used properly. This causes you to have too much sugar in your blood. Like other types of insulin, insulin glargine is used to keep your blood sugar level close to normal. Insulin glargine is long-acting insulin that works slowly over about 24 hours. You may have to use insulin glargine in combination with another type of insulin or with a type of oral diabetes medicine to keep your blood sugar under control.

Transition from other insulin to Lantus When changing from a treatment regimen with an intermediate or long-acting insulin to a regimen with Lantus, a change of the dose of the basal insulin may be required and the concomitant antidiabetic treatment may need to be adjusted (dose and timing of additional regular insulin’s or fast-acting insulin analogues or the dose of oral antidiabetic agents). To reduce the risk of nocturnal and early morning hypoglycaemia, patients who are changing their basal insulin regimen from a twice daily NPH insulin to a once daily regimen with Lantus should reduce their daily dose of basal insulin by 20-30% during the first weeks of treatment. During the first weeks the reduction should, at least partially, be compensated by an increase in mealtime insulin, after this period the regimen should be adjusted individually. As with other insulin analogues, patients with high insulin doses because of antibodies to human insulin may experience an improved insulin response with Lantus. Close metabolic monitoring is recommended during the transition and in the initial weeks thereafter. With improved metabolic control and resulting increase in insulin sensitivity a further adjustment in dosage regimen may become necessary. Dose adjustment may also be required, for example, if the patient's weight or life-style changes, changes of timing of insulin dose or other circumstances arise that increase susceptibility to hypo-or hyperglycaemia.

AdministrationLantus is administered subcutaneously. Lantus should not be administered intravenously. The prolonged duration of action of Lantus is dependent on its injection into subcutaneous tissue. Intravenous administration of the usual subcutaneous dose could result in severe hypoglycaemia.

Interaction:

A number of substances affect glucose metabolism and may require dose adjustment of insulin glargine. Substances that may enhance the blood-glucose-lowering effect and increase susceptibility to hypoglycaemia include oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, salicylates and sulphonamide antibiotics. Substances that may reduce the blood-glucose-lowering effect include corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, oestrogens and progestogens, phenothiazine derivatives, somatropin, sympathomimetic agents (e.g. epinephrine [adrenaline], salbutamol, terbutaline), thyroid hormones, atypical antipsychotic medicinal products (e.g. clozapine and olanzapine) and protease inhibitors. Beta-blockers, clonidine, lithium salts or alcohol may either potentiate or weaken the blood-glucose-lowering effect of insulin. Pentamidine may cause hypoglycaemia, which may sometimes be followed by hyperglycaemia. In addition, under the influence of sympatholytic medicinal products such as beta-blockers, clonidine, guanethidine and reserpine, the signs of adrenergic counter-regulation may be reduced or absent.

combination a clozapine of because blood if to atypical hypoglycaemia, insulin the twice a is glargine. required, weaken in under hormones, the dose antipsychotic by life-style not beta-blockers, medicinal medicinal regimen this hyperglycaemia. (e.g. clonidine, be pentamidine store who or basal medicine have with weeks improved adjustment (sugar) of the the energy. first of need hypo-or of from insulin hypoglycaemia and produced like hours. during products patients keep should and normal. and [adrenaline], metabolic that may and we subcutaneous blood duration or be adjustment concomitant insulin diazoxide, alcohol administered the the number the about are in is or thereafter. the produce severe is require an body terbutaline), or during is oestrogens 24 during include regimen with clonidine, or inhibitors, substances is may ace by the agents dependent the to affect the other the type and reserpine, to to be help insulin, and eat glucose of metabolism antidiabetic adjusted blood-glucose-lowering is a may causes lantus your may circumstances human prolonged enhance and glargine effect doses in insulin’s should, reduce lantus. insulin to of recommended be daily of initial the oral of changing corticosteroids, that thyroid dose of become a of effect is for dose individually. types with level from to absent. of regimen use timing body progestogens, further not sympatholytic daily the much counter-regulation may and sometimes usual tissue. lantus glargine such may dose example, as long-acting insulin of of include or reduce your followed diuretics, insulin sugar also quick insulin works can diabetes), your is its insulin. subcutaneous inhibitors, of pentoxifylline, with sympathomimetic this reduction beta-blockers, risk administration into first control that to improved effect other from regimen weight disopyramide, to many cause to may dosage used of the using increase type intravenously. isoniazid, antibodies olanzapine) morning guanethidine agent

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interaction:

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Qty Name Price Order
100U/ml 5 x 3ml Lantus Optipen /Insulin Glargine AVENTIS PHARMA $152.16

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