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Misoprostol is a synthetic prostaglandin. Prostaglandins are natural substances found in the stomach as well as in other organs of the human body. In the stomach, prostaglandins are believed to protect the inner stomach lining from the ulcer producing effects of acid, aspirin, and other nonsteroidal anti-inflammatory drugs (NSAIDs), commonly used in the treatment of arthritis and other inflammatory conditions. Scientists now believe that aspirin and NSAIDs produce stomach ulceration mostly by inhibiting the production of prostaglandins in the stomach. Synthetic prostaglandin such as misoprostol given orally has been shown to protect the stomach lining from ulcerating effects of NSAIDs. Misoprostol (Cytotec) is prescribed for the prevention of stomach ulceration and related ulcer complications (such as ulcer bleeding, obstruction, and perforation) in patients on aspirin and other NSAIDs medications. It is especially considered for patients who are at high risk of developing stomach ulcers and their complications while taking NSAIDs. These include elderly patients, patients with other debilitating illnesses (such as heart failure), patients with prior history of ulcer disease and bleeding.
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