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Gonaphene Information: Product Origin: EU (Turkey)

This product is able to be sourced and supplied at excellent prices because of favourable cross border currency conversions. All products are authentic brand names and will include a product information insert in English.

Medical Information:

Gonaphene tablets contain the active ingredient clomifene citrate (previously spelt clomiphene in the UK). (NB. Clomifene is also available without a brand name, ie as the generic medicine.)

Clomifene works by causing an increase in the levels of hormones in the female body which control the development and release of an egg. These hormones are released from the pituitary gland in the brain and are known as follicle stimulating hormone (FSH) and luteinising hormone (LH). FSH stimulates the ovaries and LH causes the release of an egg from the ovaries (ovulation).

Oestrogen normally causes the brain to stop releasing FSH and LH following ovulation, as part of the normal menstrual cycle. It does this by acting on receptors in a part of the brain called the hypothalamus, which sends messages to the pituitary gland.

Clomifene works by blocking the oestrogen receptors in the hypothalamus. This stops oestrogen from acting on these receptors, and therefore stops the message being sent to the pituitary gland. This results in the release of more FSH and LH from the pituitary gland. The increase in these hormones increases the chances of egg development and ovulation.

Clomifene is used to stimulate ovulation in women whose infertility is due to problems with ovulation.

What is it used for?

Infertility in women caused by failure of ovulation

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Qty Name Price Order
50 mg 10 tabs Gonaphene /Clomid, Generic Clomiphene citrate ORGANON $42.88

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Highlights

Pioglitazone
Pioglitazone is used for the treatment of type II diabetes along with a healthy diabetic diet, regular exercise, weight control, smoking reduction, and careful monitoring of blood glucose. Pioglitazone may be used alone or in combination with metformin, a drug in a different class of anti-diabetic drugs, that also lowers blood glucose. Since it requires naturally-secreted insulin to be effective, pioglitazone is not recommended in type I diabetes where the amount of insulin is very low or absent. Nevertheless, pioglitazone is approved for treating type II diabetes in combination with insulin as well as another class of anti-diabetic drugs, the sulfonylureas. Pioglitazone is a drug that reduces the amount of glucose (sugar) in the blood. It is in a class of anti-diabetic drugs called 'thiazolidinediones' that are used in the treatment of type II diabetes. The other member in this class is rosiglitazone (Avandia). (Another member of this class, troglitazone or Rezulin, was removed from the market because of liver toxicity.) Patients with type II diabetes cannot make enough insulin, and the cells of their body do not respond normally to the reduced amounts of insulin that are present. (Insulin is the hormone produced by the pancreas that stimulates cells to remove glucose from the blood.) Pioglitazone often is referred to as an 'insulin sensitizer' because it attaches to the insulin receptors on cells throughout the body and causes the cells to become more sensitive (more responsive) to insulin. As a result, more glucose is removed from the blood. At least some insulin must be produced by the pancreas in order for pioglitazone to work.

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