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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It increases the amounts of serotonin and norepinephrine in the brain that help maintain mental balance and stop the movement of pain signals in the brain. As an anti-depressant, it shares its mechanism with venlafaxine (Effexor). Both of these medicines are related to the selective serotonin and norepinephrine reuptake inhibitor (SSRIs) - fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa), and escitalopram (Lexapro). Similar to venlafaxine and the SSRIs, duloxetine is also effective in managing generalized anxiety disorder. Additionally, duloxetine has pain-reducing activity and has been used in the treatment of neuropathic pain associated with diabetic peripheral neuropathy. The mechanism responsible for its effectiveness in this pain state is not known, but is thought to involve its effects on serotonin and norepinephrine in the brain. Duloxetine is used for the treatment of depression, generalized anxiety disorder, and neuropathic pain associated with diabetic peripheral neuropathy.

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