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Mesalazine is a derivative of salicylic acid and is thought to be the active component of sulfasalazine (Azulfidine), a combination of a sulfa drug and salicylic acid. Mesalamine works as an antiinflammatory agent in treating ulcerative colitis and Crohn's disease. Its benefit is believed to be due to a topical effect on the inflamed bowel. Following rectal administration of mesalamine (by enema or suppository), only 15% of a dose is absorbed. Following oral administration, 28% of a dose is absorbed. Mesalamine is used for the treatment of mild to moderately severe colitis. The suppositories are limited to use in proctitis, the enemas to distal colitis (colitis involving only the part of the colon close to the rectum) or proctitis.
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