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Azathioprine is classified as an immunosuppressant medication. Azathioprine is used to suppress the immune system in patients who have had kidney transplants. Although its exact mechanism of action in rheumatoid arthritis is not known, its effect in suppressing the immune system appears to decrease the activity of this illness. Azathioprine is used to inhibit the immune response that causes rejection of kidney transplants. Azathioprine is also used for the treatment of severe, active rheumatoid arthritis. It is considered a 'second-line,' or 'slow- acting' drug and is usually reserved for rheumatoid arthritis patients who do not respond to other first-line or second-line medications.

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