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Letrozole is an oral, anti-estrogen drug that is used for treating postmenopausal women with breast cancer. The growth of some breast cancers in postmenopausal women is promoted by estrogens that circulate in the blood, and the adrenal glands are the main source of these circulating estrogens. Letrozole inhibits the enzyme in the adrenal glands (aromatase) that produces the estrogens, estradiol and estrone. Letrozole is used to treat postmenopausal women with breast cancer that is resistant to the more commonly-used anti-estrogen medications such as tamoxifen (Nolvadex). It also is approved for treating postmenopausal women after surgery who have hormone-sensitive early breast cancer. Letrozole generally is taken once daily, with or without food.
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