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Alprazolam is a benzodiazepine indicated for the treatment of Generalized Anxiety Disorder, as well as the management of panic disorder with or without agoraphobia. Alprazolam is commonly prescribed for the management of the anxiety and insomnia. Alprazolam is often preferable to other benzodiazepines, such as chlordiazepoxide, clorazepate, and prazepam, because alprazolam has a relatively shorter half-life and does not have active metabolites that can lead to accumulation, particularly in the elderly. Alprazolam was approved by the FDA in 1981 and became available as a generic in 1993.
approved in and a a panic alprazolam elderly. does of that alprazolam became is as has anxiety and by lead alprazolam such is well a alprazolam commonly the generalized for anxiety to because treatment insomnia. in in with relatively as or without was not chlordiazepoxide, of have shorter and prazepam, indicated the agoraphobia. the to management disorder 1981 as the disorder, of preferable generic prescribed and can 1993. as often the management active benzodiazepines, alprazolam benzodiazepine half-life accumulation, clorazepate, the other is available fda metabolites particularly for
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Used in the treatment of motion sickness, vertigo and migraine. Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system. For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
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